Application of a Hyaluronic Acid Gel after Intrauterine Surgery May Improve Spontaneous Fertility: A Randomized Controlled Trial in New Zealand White Rabbits |
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| Authors: | Stephanie Huberlant Herve Fernandez Pierre Vieille Mohamed Khrouf Daniela Ulrich Renaud deTayrac Vincent Letouzey |
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| Affiliation: | 1Department of Obstetrics and Gynaecology, Nimes University Hospital, Nîmes, France;2Department of Obstetrics and Gynaecology, Hôpital de Bicêtre- Assistance Publique- Hopîtaux de Paris, Le Kremlin-Bicêtre, Paris, France;Queen''s University, CANADA |
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| Abstract: | ObjectiveIntrauterine adhesions (IUAs) are the most common complication after hysteroscopy in patients of reproductive age. Intra-abdominal anti-adhesion gel reduces the incidence of adhesions, but effects on fertility after uterine surgery are not known. The objective of our work was to evaluate the effect of intrauterine anti-adhesion gel on spontaneous fertility after repeated intrauterine surgery with induced experimental synechiae in the rabbit model.ResultsThere was a significant difference in total fetuses in favor of group A, with an average of 3.7 (range, 0–9) total fetuses per tube against 2.1 (0–7) in group B (p = .04). The number of viable fetuses shows a trend in favor of group A, with an average of 3.4 (0–7) viable fetuses per tube against 1.9 (0–6) viable fetuses per tube in group B (p = .05).ConclusionThe use of immediate postoperative anti-adhesion gel improved fertility in an animal model after intrauterine surgery likely to cause uterine synechiae. This experimental model will permit comparison of different anti-adhesion solutions, including assessment of their tolerance and potential mucosal toxicity on embryonic development. |
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