Metabolic Profile in Early Pregnancy Is Associated with Offspring Adiposity at 4 Years of Age: The Rhea Pregnancy Cohort Crete,Greece |
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| Authors: | Vasiliki Daraki Vaggelis Georgiou Stathis Papavasiliou Georgia Chalkiadaki Marianna Karahaliou Stella Koinaki Katerina Sarri Maria Vassilaki Manolis Kogevinas Leda Chatzi |
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| Institution: | 1. Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece.; 2. Clinic of Endocrinology, University Hospital of Crete, Heraklion, Greece.; 3. Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.; 4. IMIM (Hospital del Mar Research Institute), Barcelona, Spain.; 5. CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain.; 6. National School of Public Health, Athens, Greece.; Karolinska Institutet, SWEDEN, |
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| Abstract: | ContextMaternal pre-pregnancy obesity may increase the risk of childhood obesity but it is unknown whether other metabolic factors in early pregnancy such as lipid profile and hypertension are associated with offspring cardiometabolic traits.ObjectiveOur objective was to investigate whether fasting lipid, glucose, and insulin levels during early pregnancy and maternal pre-pregnancy weight status, are associated with offspring adiposity measures, lipid levels and blood pressure at preschool age.ResultsPre-pregnancy overweight/obesity was associated with greater risk of offspring overweight/obesity (RR: 1.83, 95%CI: 1.19, 2.81), central adiposity (RR: 1.97, 95%CI: 1.11, 3.49), and greater fat mass by 5.10mm (95%CI: 2.49, 7.71) at 4 years of age. These associations were more pronounced in girls. An increase of 40mg/dl in fasting serum cholesterol levels in early pregnancy was associated with greater skinfold thickness by 3.30mm (95%CI: 1.41, 5.20) at 4 years of age after adjusting for pre-pregnancy BMI and several other confounders. An increase of 10mmHg in diastolic blood pressure in early pregnancy was associated with increased risk of offspring overweight/obesity (RR: 1.22, 95%CI: 1.03, 1.45), and greater skinfold thickness by 1.71mm (95% CI: 0.57, 2.86) at 4 years of age.ConclusionsMetabolic dysregulation in early pregnancy may increase the risk of obesity at preschool age. |
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