Reduced expression of neural cell adhesion molecule induces metastatic dissemination of pancreatic beta tumor cells |
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Authors: | Perl A K Dahl U Wilgenbus P Cremer H Semb H Christofori G |
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Affiliation: | Research Institute of Molecular Pathology, Vienna, Austria. |
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Abstract: | As in the development of many human cancers, in a transgenic mouse model of beta-cell carcinogenesis (Rip1Tag2), expression of neural cell adhesion molecule (NCAM) changes from the 120-kDa isoform in normal tissue to the 140/180-kDa isoforms in tumors. NCAM-deficient RiplTag2 mice, generated by crossing Rip1Tag2 mice with NCAM knockout mice, develop metastases, a tumor stage that is not seen in normal Rip1Tag2 mice. In contrast, overexpression of NCAM 120 in NCAM-deficient Rip1Tag2 mice prevents tumor metastasis. The results indicate that the loss of NCAM-mediated cell adhesion is one rate-limiting step in the actual metastatic dissemination of beta tumor cells. |
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