Influence of nitrate and nitrite on electrolyte transport by the rat small and large intestine |
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Authors: | R Würmli S Wolffram E Scharrer |
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Affiliation: | Institut für Veterin?r-Physiologie, Universit?t Zürich, Switzerland. |
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Abstract: | 1. The influence of nitrate and nitrite on net absorption of electrolytes (Na+, K+, Cl-) and water from ligated loops was studied at various intestinal sites in rats. 2. Nitrate strikingly reduced Cl- absorption in rat proximal and distal colon, whereas Na+ absorption was reduced only moderately. Nitrite also reduced Cl- absorption in the colon. 3. Nitrate showed no significant effect on electrolyte absorption in the small intestine. 4. The results suggest that Cl-/HCO3- on exchange is the major route of Cl- absorption in the colon, whereas this mechanism seems not to be of importance for Cl- absorption by the small intestine. |
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