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Evolution of allostery in the cyclic nucleotide binding module
Authors:Natarajan Kannan  Jian Wu  Ganesh S Anand  Shibu Yooseph  Andrew F Neuwald  J Craig Venter  Susan S Taylor
Institution:(1) Department of Chemistry and Biochemistry, University of California, Gilman Drive, 92093-0654 La Jolla, California, USA;(2) Department of Biological Sciences, National University of Singapore, Science Drive 4, 117543, Singapore;(3) J Craig Venter Institute, Medical Center Drive, 20850 Rockville, MD, USA;(4) Institute for Genome Sciences and Department of Biochemistry and Molecular Biology,HSF-II, University of Maryland School of Medicine, Penn Street, 21201 Baltimore, MD, USA;(5) Department of Chemistry and Biochemistry, and HHMI, University of California, Gilman Drive, 92093-0654 La Jolla, California, USA
Abstract:

Background  

The cyclic nucleotide binding (CNB) domain regulates signaling pathways in both eukaryotes and prokaryotes. In this study, we analyze the evolutionary information embedded in genomic sequences to explore the diversity of signaling through the CNB domain and also how the CNB domain elicits a cellular response upon binding to cAMP.
Keywords:
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