(+/-)-2-(3-Piperidyl)-1,2,3,4-tetrahydroisoquinolines as a new class of specific bradycardic agents |
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| Authors: | Kubota Hideki Kakefuda Akio Watanabe Toshihiro Taguchi Yasuko Ishii Noe Masuda Noriyuki Sakamoto Shuichi Tsukamoto Shin ichi |
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| Affiliation: | Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co. Ltd., 21Miyukigaoka, Tsukuba, 305-8585, Ibaraki, Japan. |
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| Abstract: | A series of (+/-)-2-(3-piperidyl)-1,2,3,4-tetrahydroisoquinolines were prepared and their bradycardic activities were examined in isolated guinea-pigs' right atria and in anesthetized rats. Modifications on the benzyl moiety of the parent compound, 1, led to the identification of compound 11e as a potent and specific bradycardic agent. |
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