Localization of the human phosphotyrosine phosphatase-related genes (h-PRL-1) to chromosome bands 1p35–p34, 17q12–q21, 11q24–q25 and 12q24 |
| |
| Authors: | M Montagna Olga Serova B S Sylla Marie-Geneviève Mattei Gilbert M Lenoir |
| |
| Institution: | (1) International Agency for Research on Cancer, 150 Cours Albert Thomas, F-69372 Lyon Cédex 08, France Tel.: +33-72-72-84-85; Fax: +33-72-73-85-75, FR;(2) INSERM U406, Unité de Génétique et Développement, Faculté de Médecine, 27 Boulevard Jean Moulin, F-13385 Marseille Cédex 5, France, FR |
| |
| Abstract: | The h-PRL-1 gene codes for a new phosphotyrosine phosphatase that may play an important role in the control of basic cellular
processes such as cell growth and proliferation. Using the cDNA of the h-PRL-1 gene as a probe, we examined a somatic mouse
and hamster × human hybrid panel and found that chromosomes 1, 17 and 11 harbor sequences homologous to h-PRL-1. By in situ hybridization of metaphase spreads, subchromosomal localizations were determined at bands 1p35–p34, 17q12– q21 and 11q24–q25;
in addition, a faint signal was detected at 12q24. The chromosomal assignment of the genes homologous to h-PRL-1 will help
the investigation of its possible involvement in human diseases involving genetic alteration at these chromosomal regions.
Received: 12 June 1996 / Revised: 27 July 1996 |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
