X-ray-induced translocations in marmoset (Callithrix jacchus) stem-cell spermatogonia |
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| Authors: | P P van Buul |
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| Institution: | 1. Department of Radiation Genetics and Chemical Mutagenicity, State University of Leiden, Wassenaarseweg 72, 2333 AL Leiden, The Netherlands;2. Interuniversity Institute for Radiopathology and Radiation Protection, Rijnsburgerweg 86 2333 AD Leiden, The Netherlands |
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| Abstract: | The induction of reciprocal translocations in spermatogonial stem cells of marmosets (Callithrix jacchus) was studied after irradiation with different doses of X-rays (50, 100 and 200 rad) via spermatocyte analysis many cell generations later. The obtained results show a dose-effect relationship with clear saturation effects at 200 rad. The recorded frequencies of translocations were much lower than those reported for closely related marmosets (Saguinus fuscicollis and Saguinus oepidus). Possible reasons for this difference are discussed. |
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