| 器官成形素调控果蝇翅芽细胞形貌的研究进展 |
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| 引用本文： | 刘素宁,王丹,沈杰. 器官成形素调控果蝇翅芽细胞形貌的研究进展[J]. 昆虫知识, 2013, 0(6): 1489-1498 |
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| 作者姓名： | 刘素宁 王丹 沈杰 |
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| 作者单位： | 中国农业大学昆虫学系,北京100193 |
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| 基金项目： | 高等学校博士学科点专项科研基金（20120008110005）;国家自然科学基金面上项目（NSFC31071696）. |
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| 摘 要： | 果蝇翅芽是研究细胞形貌发生的模式系统。在果蝇翅芽的发育过程中,器官成形素由浓度高的区域(成形素表达细胞)向浓度低的区域(接收细胞)移动,形成动态的浓度梯度。器官成形素信号通路的激活调控翅芽细胞的形貌发生、存活、生长和分化。目前已鉴定的在翅芽细胞表达的器官成形素包括Hedgehog(Hh),Decapentaplegic(Dpp)和Wingless(Wg)。结合国际最新研究进展,本文综述了3种器官成形素在翅芽细胞形貌发生过程中的重要作用,讨论了细胞形貌发生的分子机制。
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| 关 键 词： | 器官成形素 细胞形貌发生 果蝇 翅芽 |
The research progress of morphogen-regulated cell morphogenesis during Drosophlia wing disc development |
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| LIU Su-Ning WANG Dan,SHEN Jie. The research progress of morphogen-regulated cell morphogenesis during Drosophlia wing disc development[J]. Entomological Knowledge, 2013, 0(6): 1489-1498 |
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| Authors: | LIU Su-Ning WANG Dan SHEN Jie |
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| Affiliation: | (Department of Entomology,China Agricultural University,Beijing 100193,China) |
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| Abstract: | Drosophila wing disc is a good model system to study the cell morphogenesis. During the development of the larval wing discs, morphogens secrete from high concentration region to low concentration receiving ceils to form a dynamic gradient. Morphogen signaling pathways regulate the cell morphogenesis, survival, proliferation, and differentiation. Up to date, three morphogens have been identified in the wing discs, which are Hedgehog （Hh） , Decapentaplegic （Dpp） , and Wingless （Wg）. In this review, we summarize the functions and discuss the molecular mechanisms of these three morphogens in cell morphogenesis. |
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| Keywords: | morphogen cell morphogenesis Drosophila wing disc |
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