Instability in the COPD Diagnosis upon Repeat Testing Vary with the Definition of COPD |
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Authors: | Rogelio Perez-Padilla Fernando C Wehrmeister Maria Montes de Oca Maria Victorina Lopez Jose R Jardim Adriana Muino Gonzalo Valdivia Julio Pertuze Ana Maria B Menezes PLATINO group |
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Institution: | 1. Sleep Clinic, National Institute of Respiratory Diseases, Mexico City, Mexico.; 2. Faculty of Medicine, University of the Republic, Montevideo, Uruguay.; 3. Pulmonary Division, Hospital Universitario de Caracas, Universidad Central de Venezuela, Caracas, Venezuela.; 4. Postgraduate program on Epidemiology, Federal University of Pelotas, Pelotas, Brazil.; 5. Pontificia Universidad Catolica de Chile, Santiago, Chile.; 6. Federal University of Sao Paulo, Sao Paulo, Brazil, |
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Abstract: | BackgroundA low FEV1/FVC from post-bronchodilator spirometry is required to diagnose COPD. Both the FEV1 and the FVC can vary over time; therefore, individuals can be given a diagnosis of mild COPD at one visit, but have normal spirometry during the next appointment, even without an intervention.MethodsWe analyzed two population-based surveys of adults with spirometry carried out for the same individuals 5-9 years after their baseline examination. We determined the factors associated with a change in the spirometry interpretation from one exam to the next utilizing different criteria commonly used to diagnose COPD.ResultsThe rate of an inconsistent diagnosis of mild COPD was 11.7% using FEV1/FVC <0.70, 5.9% using FEV1/FEV6 <the lower limit of the normal range, LLN and 4.1% using the GOLD stage 2-4 criterion. The most important factor associated with diagnostic inconsistency was the closeness of the ratio to the LLN during the first examination. Inconsistency decreased with a lower FEV1.ConclusionsUsing FEV1/FEV6 <LLN or GOLD stage 2-4 as the criterion for airflow obstruction reduces inconsistencies in the diagnosis of mild COPD. Further improvement could be obtained by defining a borderline zone around the LLN (e.g. plus or minus 0.6 SD), or repeating the test in patients with borderline results. |
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