Brain lipidomic changes after morphine,cocaine and amphetamine administration — DESI — MS imaging study |
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| Institution: | 1. Department of Biochemistry and Neurobiology, Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30 Ave, 30-059 Krakow, Poland;2. Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy, Medical University, Chodźki 4a st., 20-093 Lublin, Poland;1. Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA;2. Gill Center for Biomolecular Neuroscience, Indiana University, Bloomington, IN, USA;3. Université Paris Diderot, Sorbonne Paris Cité, Unité de Biologie Fonctionnelle et Adaptative, CNRS UMR 8251, F-75205 Paris, France;1. The Department of Bio and Fermentation Convergence Technology, BK21 PLUS program, Kookmin University, Seoul 02707, Republic of Korea;2. The Department of Psychiatry, Yonsei University College of Medicine, Seoul 03722, Republic of Korea;3. Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul 03722, Republic of Korea;4. National Health Insurance service Ilsan Hospital, Goyang, Gyunggi 10444, Republic of Korea;1. National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China;2. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China;3. College of Pharmacy, Yantai University, Yantai 264000, China |
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| Abstract: | Drug addiction is a complex disorder, evoking significant changes in the proteome of the central nervous system. To check if there are also changes in the lipidomic profiles we used desorption electrospray-MS technique for imaging of the brain slices of rats exposed to morphine, cocaine and amphetamine. Our investigations showed alternative regulation of selected lipid's levels in the central nervous system structures, under the influence of applied drugs. Results of our investigations can show changes in the brain treated with drugs of abuse in the new light, indicating role of the lipids in the addiction development. |
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