The bacillary and macrophage response to hypoxia in tuberculosis and the consequences for T cell antigen recognition |
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| Affiliation: | 1. Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD, 20892, United States;2. Microbial Interface Biology, Priority Research Area Infections, Forschungszentrum Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1-40, D-23845, Borstel, Germany;3. Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, 7925, South Africa;4. The Francis Crick Institute, London, NW1 2AT, United Kingdom;5. Department of Medicine, Imperial College, London, W2 1PG, United Kingdom;6. German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck, Borstel, Germany |
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| Abstract: | Mycobacterium tuberculosis is a facultative anaerobe and its characteristic pathological hallmark, the granuloma, exhibits hypoxia in humans and in most experimental models. Thus the host and bacillary adaptation to hypoxia is of central importance in understanding pathogenesis and thereby to derive new drug treatments and vaccines. |
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| Keywords: | Tuberculosis Hypoxia T cells Antigens Macrophage Lipid droplets |
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