LTA4H Genotype Is Associated with Susceptibility to Bacterial Meningitis but Is Not a Critical Determinant of Outcome |
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| Authors: | Sarah J Dunstan Trinh Thi Bich Tram Guy E Thwaites Tran Thi Hong Chau Nguyen Hoan Phu Tran Tinh Hien Jeremy J Farrar Marcel Wolbers Nguyen Thi Hoang Mai |
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| Institution: | 1. Oxford University Clinical Research Unit, Ho Chi Minh City, District 5, Vietnam.; 2. Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, Oxford University, Oxford, OX3 7LJ, United Kingdom.; 3. Nossal Institute of Global Health, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, 3010, Australia.; 4. Hospital for Tropical Diseases, Ho Chi Minh City, District 5, Vietnam.; University of New South Wales, AUSTRALIA, |
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| Abstract: | Adjunctive dexamethasone saves lives in the treatment of tuberculous meningitis but this response is influenced by the patient’s LTA4H genotype. Despite less certain benefit, adjunctive dexamethasone is also frequently used in the treatment of pyogenic bacterial meningitis, but the influence of LTA4H genotype on outcomes has not been previously investigated. We genotyped the LTA4H promoter region SNP (rs17525495) in 390 bacterial meningitis patients and 751 population controls. rs17525495 was associated with susceptibility to bacteriologically confirmed bacterial meningitis (P = 0.01, OR 1.27 95% confidence interval CI] 1.05–1.54) but did not influence clinical presentation, disease severity or survival following dexamethasone treatment. |
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