Known unknowns of cardiolipin signaling: The best is yet to come |
| |
| Institution: | 1. Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA 15219, USA;2. Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, USA;3. Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15260, USA;4. Division of Metabolic and Vascular Health, Medical School, University of Warwick, Coventry CV47AL, UK;5. Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA;6. Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA;7. Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15260, USA;1. Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, H166, Hershey, PA 17033, United States;2. Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, Texas Research Park, MC7755, 15355 Lambda Drive, San Antonio, TX 78245, United States;1. Institute for Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany;2. Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany;3. BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany;1. Department of Biochemistry II, University Medical Center Göttingen, Humboldtallee 23, 37073 Göttingen, Germany;2. Department of Cardiology and Pneumology, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany;3. DZHK (German Center for Cardiovascular Research), partner site Göttingen, Germany;4. Laboratory Genetic Metabolic Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands;5. Max-Planck Institute for Biophysical Chemistry, Am Faßberg 11, 37077 Göttingen, Germany |
| |
| Abstract: | Since its discovery 75 years ago, a wealth of knowledge has accumulated on the role of cardiolipin, the hallmark phospholipid of mitochondria, in bioenergetics and particularly on the structural organization of the inner mitochondrial membrane. A surge of interest in this anionic doubly-charged tetra-acylated lipid found in both prokaryotes and mitochondria has emerged based on its newly discovered signaling functions. Cardiolipin displays organ, tissue, cellular and transmembrane distribution asymmetries. A collapse of the membrane asymmetry represents a pro-mitophageal mechanism whereby externalized cardiolipin acts as an “eat-me” signal. Oxidation of cardiolipin's polyunsaturated acyl chains - catalyzed by cardiolipin complexes with cytochrome c. - is a pro-apoptotic signal. The messaging functions of myriads of cardiolipin species and their oxidation products are now being recognized as important intracellular and extracellular signals for innate and adaptive immune systems. This newly developing field of research exploring cardiolipin signaling is the main subject of this review. This article is part of a Special Issue entitled: Lipids of Mitochondria edited by Guenther Daum. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
