The evolution of lipidomics through space and time |
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Institution: | 1. Division of Bioorganic Chemistry & Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8020, Saint Louis, MO 63110, USA;2. Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA;3. Department of Chemistry, Washington University, Saint Louis, MO 63130, USA;1. Department of Chemistry, Örebro University, 702 81 Örebro, Sweden;2. Steno Diabetes Center A/S, DK-2820 Gentofte, Denmark;3. Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland;4. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, FI-20520 Turku, Finland;1. Post-graduation Program in Interactive Processes of Organs and Systems, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, Brazil;2. Institute of Health Sciences-ICS, Federal University of Bahia-UFBA, Department of Biofunção, Laboratory of Biochemistry, Biotechnology and Bioproducts-LBBB, Salvador, Bahia, Brazil |
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Abstract: | Although the foundations of mass spectrometry-based lipidomics have been practiced for over 30 years, recent technological advances in ionization modalities in conjunction with robust increases in mass accuracy and resolution have greatly accelerated the emergence, growth and importance of the field of lipidomics. Moreover, advances in the separation sciences, bioinformatic strategies and the availability of robust databases have been synergistically integrated into modern lipidomic technologies leading to unprecedented improvements in the depth, penetrance and precision of lipidomic analyses and identification of their biological and mechanistic significance. The purpose of this "opinion" article is to briefly review the evolution of lipidomics, critique the platforms that have evolved and identify areas that are likely to emerge in the years to come. Through seamlessly integrating a rich repertoire of mass spectrometric, chemical and bioinformatic strategies, the chemical identities and quantities of tens of thousands to hundreds of thousands of different lipid molecular species and their metabolic alterations during physiologic or pathophysiologic perturbations can be obtained. Thus, the field of lipidomics which already has a distinguished history of exciting new discoveries in many disease states holds unparalleled potential to identify the pleiotropic roles of lipids in health and disease at the chemical level. This article is part of a Special Issue entitled: BBALIP_Lipidomics Opinion Articles edited by Sepp Kohlwein. |
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