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Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection
Affiliation:1. Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge University Hospitals, Hills Road, Cambridge, CB2 0QQ, UK;2. Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield Medical School, Beech Hill Road, Sheffield, S10 2RX, UK;1. Institute of Physiology, Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland;2. Division of Transplant Surgery, Department of Surgery, Rush University Medical Center, Chicago, IL;3. Department of Surgery, Cantonal Hospital Winterthur, Canton of Zürich, Switzerland;4. Institute of Anesthesiology, University Hospital Zürich, Zürich, Switzerland;5. Department of Anesthesiology, University of Illinois Chicago, Chicago, IL;1. Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH;2. Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH;1. Department of Digestive and Hepatobiliary Surgery, Estaing hospital, CHU Clermont-Ferrand, 1 Place Lucie et Raymond Aubrac, Clermont-Ferrand, France;2. Department of Vascular Radiology, Gabriel Montpied hospital, CHU Clermont-Ferrand, Place Henri Dunant, Clermont-Ferrand, France;3. Department of Surgical Oncology, Léon Bérard Cancer Centre, Lyon, France;1. Department of Medicine, University of Washington, Seattle, Washington, USA;2. Department of Medicine, St. John Hospital Medical Center, Detroit, Michigan, USA;3. Department of Medicine, Wayne State University, Detroit, Michigan, USA;4. Department of Medicine, University of Arizona, Tucson, Arizona, USA;5. Department of Medicine, Temple University, Philadelphia, Pennsylvania, USA;6. Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA;7. Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA;8. Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA
Abstract:Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.
Keywords:Neutrophil  Hypoxia
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