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Full-genome sequences of hepatitis B virus subgenotype D3 isolates from the Brazilian Amazon Region
Authors:Natália Spitz  Francisco CA Mello  Natalia Motta Araujo
Affiliation:1.Laboratório de Virologia Molecular, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil;2.Departamento de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói, RJ, Brasil
Abstract:The Brazilian Amazon Region is a highly endemic area for hepatitis B virus (HBV).However, little is known regarding the genetic variability of the strains circulatingin this geographical region. Here, we describe the first full-length genomes of HBVisolated in the Brazilian Amazon Region; these genomes are also the first completeHBV subgenotype D3 genomes reported for Brazil. The genomes of the five Brazilianisolates were all 3,182 base pairs in length and the isolates were classified asbelonging to subgenotype D3, subtypes ayw2 (n = 3) and ayw3 (n = 2). Phylogeneticanalysis suggested that the Brazilian sequences are not likely to be closely relatedto European D3 sequences. Such results will contribute to further epidemiological andevolutionary studies of HBV.
Keywords:HBV   complete genome   amino acid residues   genetic distance
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