Full-genome sequences of hepatitis B virus subgenotype D3 isolates from
the Brazilian Amazon Region |
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| Authors: | Natália Spitz Francisco CA Mello Natalia Motta Araujo |
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| Institution: | 1.Laboratório de Virologia Molecular, Instituto Oswaldo Cruz-Fiocruz, Rio de Janeiro, RJ, Brasil;2.Departamento de Microbiologia e Parasitologia, Universidade Federal Fluminense, Niterói, RJ, Brasil |
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| Abstract: | The Brazilian Amazon Region is a highly endemic area for hepatitis B virus (HBV).
However, little is known regarding the genetic variability of the strains circulating
in this geographical region. Here, we describe the first full-length genomes of HBV
isolated in the Brazilian Amazon Region; these genomes are also the first complete
HBV subgenotype D3 genomes reported for Brazil. The genomes of the five Brazilian
isolates were all 3,182 base pairs in length and the isolates were classified as
belonging to subgenotype D3, subtypes ayw2 (n = 3) and ayw3 (n = 2). Phylogenetic
analysis suggested that the Brazilian sequences are not likely to be closely related
to European D3 sequences. Such results will contribute to further epidemiological and
evolutionary studies of HBV. |
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| Keywords: | HBV complete genome amino acid residues genetic distance |
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