Antihepatotoxic effect of beta-carotene on paracetamol induced hepatic damage in rats |
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Authors: | Kumar G Banu G Sharmila Kannan V Pandian M Rajasekara |
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Affiliation: | Department of Life Science, Selvamm Arts and Science College, Namakkal, India. pgsvedhakumar@yahoo.com |
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Abstract: | Enzyme levels of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) increased following paracetamol induction were significantly lowered due to pretreatment with the beta-carotene (BC). This supplementation reversed the trend inducing a significant decrease in bilirubin and urea levels. Paracetamol administration significantly reduced hepatic glycogen, glutathione (GSH), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reductase (GSH-R). Pretreatment of rats with BC significantly increased the enzyme activities. The results suggest hepatoprotective activity of BC. |
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