The activation of a neuralizing factor in the neural plate is correlated with its homoiogenetic-inducing activity |
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Authors: | Horst Grunz Jochen Born Heinz Tiedemann Hildegard Tiedemann |
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Affiliation: | (1) Abteilung für Biologie (Zoophysiologie), Universität Essen, Universitätsstraße 5, D-4300 Essen 1, Germany;(2) Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Arnimallee 22, D-1000 Berlin 33 |
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Abstract: | Summary Neural plates which are induced in the dorsal ectoderm of Triturus by the underlying mesoderm acquire, in turn, neural-inducing activity. This process is correlated with the appearance of neural-inducing activity in the microsomal fraction of the neural plate homogenate. The high-speed supernatant also acquires inducing activity after neural induction, but to a lesser extent. The experiments suggest that a masked neuralizing factor, which is already present in the ectoderm, is in part activated and exported from the inducing neural plate cells. |
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Keywords: | Neural induction Neural plate Activation of masked factor |
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