Plexin signaling via off-track and rho family GTPases |
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Authors: | Whitford K L Ghosh A |
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Affiliation: | Howard Hughes Medical Institute, Cardiology Department, Children's Hospital, 1309 Enders Building, 320 Longwood Avenue, Children's Hospital, 02115, Boston, Massachusetts 02115, USA. |
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Abstract: | Two papers in this issue of Neuron examine new aspects of Semaphorin signaling via Plexin receptors. Winberg et al. present evidence that the transmembrane protein Off-track (OTK) interacts biochemically and genetically with Plexin A and is important for Sema 1a repulsive signaling. Hu et al. examine the coupling of Plexin B to Rac and RhoA and propose that Plexin B signaling involves inhibition of Rac function by direct sequestration and simultaneous activation of RhoA. |
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