Differences in specificity and catalytic efficiency between allozymes of esterase-4 from Drosophila mojavensis |
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Authors: | Pen J; Schipper A; Rongen HA; Beintema JJ |
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Institution: | Biochemical Laboratory, Rijksuniversiteit Groningen, The Netherlands. |
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Abstract: | A more than 10-fold difference in the specificity and catalytic efficiency
for 1-naphthyl esters was measured between two allozymes of esterase-4 from
Drosophila mojavensis. This difference is mainly caused by a difference in
the affinity for the 1-naphthyl esters. The amino acid compositions of the
allozymes are not significantly different, which means that the difference
in primary structure is small. Small differences in primary structure
generally do not result in such a large increase in catalytic efficiency
and such a large shift in substrate specificity as was found in the present
study.
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