Kahiricosides II-V, cycloartane glycosides from an Egyptian collection of Astragalus kahiricus |
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| Authors: | Radwan Mohamed M El-Sebakhy Nadia A Asaad Aya M Toaima Soad M Kingston David G I |
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| Affiliation: | Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, 3111 Hahn Hall, MC 0212, Blacksburg, VA 24061-0212, USA. |
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| Abstract: | Four cycloartane-type saponins, kahiricosides II-V (1-4), were isolated from the aerial parts of Astragalus kahiricus of Egyptian origin. Their structures were established as 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-beta-D-glucopyranoside, 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-(2'-O-acetyl)-beta-D-glucopyranoside, 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-(6'-O-acetyl)-beta-D-glucopyranoside, and 9beta,19-cyclolanost-24E-ene-3beta,6alpha,16beta,27-tetraol-3-O-beta-D-glucopyranosyl-27-O-beta-D-glucopyranoside based on chemical and spectral evidences. All compounds exhibited very weak cytotoxicity against the A2780 ovarian cancer cell line. |
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| Keywords: | Astragalus Leguminosae Astragalus kahiricus Cycloartane-type saponins Cytotoxic activity A2780 ovarian cancer cell line |
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