GMR sensors: magnetoresistive behaviour optimization for biological detection by means of superparamagnetic nanoparticles |
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Authors: | Manteca A Mujika M Arana S |
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Institution: | CEIT, Paseo de Manuel Lardizábal, N° 15, 20018 Donostia-San Sebastián, Spain. aiaiaitor@gmail.com |
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Abstract: | An immunomagnetic method for the selective and quantitative detection of biological species by means of a magnetoresistive biosensor and superparamagnetic particles has been optimized. In order to achieve this, a giant magnetoresistive Co (5.10nm)/Cu (2.47 nm)](20) multilayer structure has been chosen as the sensitive material, showing a magnetoresistance of 3.60% at 215 Oe and a sensitivity up to 0.19 Ω/Oe between 145 Oe and 350 Oe. The outward gold surface of the sensor is biofunctionalized with a Self-Assembled Monolayer (SAM). In addition, three different types of magnetic labels have been tested. 2 μm diameter magnetic carriers (7.68 pg ferrite/particle) have shown the best response and they have induced a shift in the magnetoresistive hysteresis loops up to 9% at 175 Oe. |
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