Per-N-methylated analogues of an antitumor bicyclic hexapeptide RA-VII |
| |
Authors: | Hitotsuyanagi Yukio Lee Ji-Ean Kato Saori Kim Ik-Hwi Kohashi Hideyuki Fukaya Haruhiko Takeya Koichi |
| |
Affiliation: | School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan. |
| |
Abstract: | Penta-N-methyl and hexa-N-methyl analogues of RA-VII, an antitumor bicyclic hexapeptide of plant origin, were prepared. In the former, the nitrogens of d-Ala-1 and Ala-4 and in the latter, those of d-Ala-1, Ala-2, and Ala-4 were methylated under the phase-transfer catalysis conditions. Their solution structures were established by NOESY experiments and the crystal structures by X-ray crystallography. Those two methylated analogues showed much weaker cytotoxicity against P-388 leukemia cells than the parent RA-VII. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|