Nisin-Controlled Extracellular Production of Interleukin-2 in Lactococcus lactis Strains, without the Requirement for a Signal Peptide Sequence |
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| Authors: | Antonio Fernndez Juan M Rodríguez Roy J Bongaerts Michael J Gasson and Nikki Horn |
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| Institution: | Antonio Fernández, Juan M. Rodríguez, Roy J. Bongaerts, Michael J. Gasson, and Nikki Horn |
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| Abstract: | Secretion of the cytokine interleukin-2 (IL-2) was investigated in Lactococcus lactis using the secretory machinery of the bacteriocin lactococcin A. Surprisingly, the lcnCD transport genes were not essential for mouse IL-2 secretion. Furthermore, expression of a mature mouse IL-2 gene resulted in interleukin secretion without the requirement for a leader sequence. |
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