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DNA Topoisomerase I Domain Interactions Impact Enzyme Activity and Sensitivity to Camptothecin |
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| Authors: | Christine M Wright Marié van der Merwe Amanda H DeBrot Mary-Ann Bjornsti |
| Institution: | From the ‡Department of Pharmacology and Toxicology, University of Alabama at Birmingham, Birmingham, Alabama 35294 and ;§Department of Molecular Pharmacology, St. Jude Children''s Research Hospital, Memphis, Tennessee 38105 |
| Abstract: | |
| Keywords: | Anticancer Drug DNA Topoisomerase Protein Chimera Protein Domain Saccharomyces cerevisiae Camptothecin |