Comparative study of behavioural tests in the SOD1G93A mouse model of
amyotrophic lateral sclerosis |
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Authors: | Sara OLIVáN Ana Cristina CALVO Amaya RANDO María Jesús MU?OZ Pilar ZARAGOZA Rosario OSTA |
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Institution: | LAGENBIO-I3A, Facultad de Veterinaria, IIS Aragón, Universidad de Zaragoza, Miguel Servet 177, 50013 Zaragoza, Spain |
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Abstract: | In preclinical trials, a sensitive functional test is required to detect changes in the
motor behaviour of the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS). We
evaluated changes in body weight and motor impairment in behavioural tests, such as the
rotarod, the hanging-wire test and the treadmill, of transgenic and wild type mice. We
found differences in detection of the onset of symptoms and progression of the disease
between the different tests assessed. Moreover, the data showed significant gender
differences in the motor behaviour of this mouse model. The rotarod and the hanging-wire
test were more sensitive to detect early motor impairment. Moreover, the results suggested
that the rotarod and hanging-wire became the most accurate tests rather than treadmill to
characterise the ALS disease phenotype. |
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Keywords: | Amyotrophic lateral sclerosis hanging-wire test rotarod SOD1G93A mice treadmill |
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