In vitro inhibitory potential of Cynara scolymus,Silybum marianum,Taraxacum officinale,and Peumus boldus on key enzymes relevant to metabolic syndrome |
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| Institution: | 1. Institute for Pharma Technology, School of Life Sciences, University of Applied Sciences Northwestern Switzerland, Gründenstrasse 40, CH-4132 Muttenz, Switzerland;2. Bioforce AG, Grünaustrasse 4, CH-9325 Roggwil, Switzerland;1. CONACYT - Centro de Investigación en Alimentación y Desarrollo A.C., Carretera a ElDorado Km. 5.5, Col. Campo El Diez, Culiacán, Sinaloa 80110, Mexico.;2. Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología-FEMSA, Av. Eugenio Garza Sada 2501 Sur, CP 64849 Monterrey, N.L., Mexico.;3. Tecnologico de Monterrey, Escuela de Ingeniería y Ciencias, Campus Puebla, Vía Atlixcáyotl 2301, Reserva Territorial Atlixcáyotl, CP 72453 Puebla, Pue, Mexico. |
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| Abstract: | Boldocynara®, a proprietary dietary supplement product consisting of the plants Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus boldus, used to promote functions of the liver and the gallbladder. It was the aim of the present study to look from a different perspective at the product by investigating the in vitro potential of Boldocynara® as a combination product and its individual extracts on key enzymes relevant to metabolic syndrome. Peumus boldus extract exhibited pronounced inhibitory activities on α-glucosidase (80% inhibition at 100 µg/ml, IC50: 17.56 µg/ml). Silybum marianum had moderate pancreatic lipase (PL) inhibitory activities (30% at 100 µg/ml) whereas Cynara scolymus showed moderate ACE inhibitory activity (31% at 100 µg/ml). The combination had moderate to weak effects on the tested enzymes. In conclusion, our results indicate some moderate potential of the dietary supplement Boldocynara® and its single ingredients for the prevention of metabolic disorders. |
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