Cell and tissue cultures ofCatharanthus roseus (L.) G. Don: a literature survey |
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| Authors: | Robert Van Der Heijden Robert Verpoorte Hens J. G. Ten Hoopen |
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| Affiliation: | (1) Department of Pharmacognosy, Center for Bio-Pharmaceutical Sciences, Leiden University, P.O. Box 9502, 2300 RA Leiden, the Netherlands;(2) Department of Biochemical Engineering, Delft University of Technology, Julianalaan 67, 2628 BC Delft, the Netherlands |
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| Abstract: | The literature concerning the formation of secondary metabolites in cell and tissue cultures ofCatharanthus roseus has been reviewed. Several aspects involved in the formation of secondary metabolites are discussed; e.g. regulation of secondary metabolism, environmental factors influencing secondary metabolism, biosynthesis and enzymology of the products, analysis of product formation, immobilization of cultured cells and stability of cell lines. Some economical aspects of production processes are discussed. |
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| Keywords: | Catharanthus cell culture indole alkaloid review tissue culture |
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