In vitro platelet antiaggregatory properties of 4-methylcoumarins |
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| Authors: | Kateřina Macáková Zuzana Řeháková Přemysl Mladěnka Jana Karlíčková Tomáš Filipský Michal Říha Ashok K Prasad Virinder S Parmar Luděk Jahodář Petr Pávek Radomír Hrdina Luciano Saso |
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| Institution: | 1. Department of Pharmaceutical Botany and Ecology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic;2. Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic;3. Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India;4. Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Piazzale Aldo Moro 5, Rome, Italy |
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| Abstract: | Platelets play a crucial role in physiological haemostasis. However, in coronary arteries damaged by atherosclerosis, enhanced platelet aggregation, with subsequent thrombus formation, is a precipitating factor in acute myocardial infarction. Current therapeutic approaches are able to reduce approximately one quarter of cardiovascular events, but they are associated with an increased risk of bleeding and in some resistant patients are not efficient. Some coumarins possess antiplatelet activity and, due to their additional antioxidant effects, may be promising drugs for use in combination with the present therapeutic agents. |
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| Keywords: | Coumarins Platelet Antiaggregatory Acetylsalicylic acid Arachidonic acid |
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