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| 大黄素降糖及改善脂质代谢的实验研究 | |
| 引用本文： | 朱红球,梁丽梅,王沛坚,陈格.大黄素降糖及改善脂质代谢的实验研究[J].现代生物医学进展,2011,11(14):2624-2627. |
| 作者姓名： | 朱红球 梁丽梅 王沛坚 陈格 |
| 作者单位： | 1. 广东省医学科学院广东省人民医院药学部,广东广州,510080 2. 第三军医大学大坪医院,重庆,400020 3. 广州白云山制药厂,广东广州,510515 |
| 摘 要： | 目的:探讨大黄素对2型糖尿病模型db/db小鼠血糖及血脂水平的影响.方法:4周龄16只db/db雄性小鼠随机分为治疗组和对照组,每组8只;治疗组经灌胃每天给予100mg/kg大黄素;对照组灌胃给予相仿体积的生理盐水,开始10天每天算进食量,每周测空腹血糖及体重1次,连续干预8周,干预前及实验结束前1周测胰岛素耐量,干预结束后于颈动脉取血测血脂水平(HDLC、LDL-C、TG、TC).结果:①大黄素干预不影响db/db小鼠的进食量,与对照组比较,P＞0.05;②大黄素可显著减轻db/db小鼠体重,与对照组比较,P＜0.05;③大黄素可改善db/db小鼠胰岛素敏感性,降低小鼠的空腹血糖水平,与对照组比较,P＜0.05或P＜0.01;④大黄素可降低db/db小鼠血TG、TC、LDL-C水平,P＜0.01.结论:大黄素可有效地改善db/db小鼠的糖脂紊乱状态,其降糖及改善血脂代谢机制值得进一步深入研究. |
| 关 键 词： | 大黄素 db/db小鼠 血糖 血脂 实验研究 |
Effect of Emodin on Blood Glucose and Lipid in Mice Model with Type 2 Diabetes |
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| ZHU Hong-qiu,LIANG Li-mei,WANG Pei-jian,CHEN Ge.Effect of Emodin on Blood Glucose and Lipid in Mice Model with Type 2 Diabetes[J].Progress in Modern Biomedicine,2011,11(14):2624-2627. | |
| Authors: | ZHU Hong-qiu LIANG Li-mei WANG Pei-jian CHEN Ge |
| Institution: | ZHU Hong-qiu1,LIANG Li-mei1,WANG Pei-jian2,CHEN Ge3(1 Guangdong Academy of Medical Sciences,Guangdong General Hospital,Department of Pharmacy,Guangzhou 510080,China,2 Daping Hospital,Third Military Medical University,Institute of Hypertension 400020,3 Guangzhou Baiyunshan Pharmaceuticals Company,Guangzhou,Guangdong 510515,China) |
| Abstract: | Objective: To study the effects of emodin to the glucose and lipid levels on type 2 diabetic model db/db mice.Methods: 4-week-old db / db mice were randomly divided into treatment group and control group,each group 8 mice;treatment group were given 100mg/kg per day by administration;the control group were given similar volume of saline,To start,count food intake per day for 10 days,fasting blood glucose and body weight were measured every week,all the mice were intervention for 8 weeks,before intervention a... |
| Keywords: | Emodin db/db mice Blood glucose Lipid Experiment study |
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