Type II Transmembrane Serine Proteases |
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| Authors: | Thomas H. Bugge Toni M. Antalis Qingyu Wu |
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| Affiliation: | From the ‡Proteases and Tissue Remodeling Section, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, ;the §Center for Vascular and Inflammatory Disease and Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, and ;the ¶Departments of Molecular Cardiology and Nephrology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195 |
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| Abstract: | Analysis of genome and expressed sequence tag data bases at the turn of the millennium unveiled a new protease family named the type II transmembrane serine proteases (TTSPs) in a Journal of Biological Chemistry minireview (Hooper, J. D., Clements, J. A., Quigley, J. P., and Antalis, T. M. (2001) J. Biol. Chem. 276, 857–860). Since then, the number of known TTSPs has more than doubled, and more importantly, our understanding of the physiological functions of individual TTSPs and their contribution to human disease has greatly increased. Progress has also been made in identifying molecular substrates and endogenous inhibitors. This minireview summarizes the current knowledge of the rapidly advancing TTSP field. |
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