Synthesis and antisense properties of oligodeoxyribonucleotides containing C5-substituted arabinofuranosyluracil |
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| Authors: | Ozaki Hiroaki Nakajima Kiyohiro Kuwahara Masayasu Sawai Hiroaki |
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| Institution: | Department of Chemistry, Faculty of Engineering, Gunma University, 1-5-1 Tenjin-cho, Kiryu, Gunma 376-8515, Japan. ozaki@chem.gunma-u.ac.jp |
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| Abstract: | An oligodeoxyribonucleotide (ODN) containing three C5-substituted arabinofuranosyluracils was synthesized by the post-synthetic modification method from the ODN containing three C5-substituted 2,2'-anhydrouridines. The stability of the modified ODN/DNA duplex was lower than that of the corresponding normal duplex but that of the modified ODN/RNA duplex showed little change. The modified ODN could induce RNase H activity and was resistant against nuclease. |
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