首页 | 本学科首页   官方微博 | 高级检索  
     


Mechanism of activation of the external pathway of NADH oxidation in myocardial mitochondria during hemorrhagic shock
Authors:G G Shamkulashvili  G G Dumbadze  N D Nanobashvili  T V Mchedlishvili  M V Papava
Abstract:The changes in the oxidative metabolism of rabbit myocardium in hemorrhagic shock were studied. The external pathway of NADH oxidation was shown to be activated, while the rates of glutamate oxidation in the presence of an uncoupler were diminished as compared to control values. These changes are probably due to the activation of phospholipase A2 and lipid peroxidation, since their inhibitors eliminate with the same efficiency the activation of the external pathway of NADH oxidation both in normal and damaged myocardium.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号