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Alternative splicing and protein function
Authors:AD?Neverov,II?Artamonova,RN?Nurtdinov,D?Frishman,MS?Gelfand  author-information"  >  author-information__contact u-icon-before"  >  mailto:gelfand@iitp.ru"   title="  gelfand@iitp.ru"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author,AA?Mironov
Affiliation:1.State Scientific Center GosNIIGenetika,Moscow,Russia;2.Institute for Bioinformatics/MIPS, GSF – National Research Center for Environment and Health,Neuherberg,Germany;3.Department of Bioengineering and Bioinformatics,M.V.Lomonosov Moscow State University,Moscow,Russia;4.Department of Genome Oriented Bioinformatics,Technical University of Munich, Wissenschaftszentrum Weihenstephan,Freising,Germany;5.Institute for Information Transmission Problems RAS,Moscow,Russia
Abstract:

Background  

Alternative splicing is a major mechanism of generating protein diversity in higher eukaryotes. Although at least half, and probably more, of mammalian genes are alternatively spliced, it was not clear, whether the frequency of alternative splicing is the same in different functional categories. The problem is obscured by uneven coverage of genes by ESTs and a large number of artifacts in the EST data.
Keywords:
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