A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi |
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| Authors: | Nanting Ni Minyong Li |
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| Affiliation: | a Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Campus Box 4098, Atlanta, GA 30302-4098, USA
b Department of Biology, Georgia State University, Atlanta, GA 30302-4010, USA |
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| Abstract: | Quorum sensing has attracted much attention due to its involvement in pathologically relevant events such as biofilm formation, virulence factor production, and sporulation. Inhibitors of quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe a phenothiazine structural scaffold as a new type of quorum sensing inhibitors with IC50 values in the single digit micro molar range in Vibrio harveyi. |
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| Keywords: | MM32 Autoinducer-1 Autoinducer-2 |
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