Heat shock protein 27 in neuronal survival and neurite outgrowth |
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Authors: | Danielle E. Read |
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Affiliation: | Cell Death and Survival Group, Department of Biochemistry, School of Natural Sciences, National University of Ireland, Galway, Ireland National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland |
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Abstract: | The small heat shock protein 27 (Hsp27) is well documented to promote neuronal survival in neurodegenerative diseases and following nerve injury. It can directly inhibit apoptotic pathways, and as a chaperone it can ameliorate the toxic effects of misfolded proteins. More recently, Hsp27 has been implicated to also play a role in neurite outgrowth. Thus, Hsp27 is situated at the intersection of neuronal survival and differentiation and, as such, it has dual potential as a key therapeutic target for neuroregeneration. |
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Keywords: | Akt Cell death Neurodegeneration Neuroregeneration |
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