Parvovirus capsid disorders cholesterol-rich membranes |
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| Authors: | Kirsi Pakkanen Nina Rintanen Matti Vuento |
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| Affiliation: | Department of Biological and Environmental Science and Nanoscience Center, P.O. Box 35, FIN-40014 University of Jyväskylä, Finland |
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| Abstract: | In this study canine parvovirus, CPV, was found to induce disorder in DPPC:cholesterol membranes in acidic conditions. This acidicity-induced fluidizing effect is suggested to originate from the N-terminus of the viral capsid protein VP1. In accordance with the model membrane studies, a fluidizing effect was seen also in the endosomal membranes during CPV infection implying an important functional role of the fluidization in the endocytic entry of the virus. |
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| Keywords: | Virus capsid Membrane disorder Cholesterol-rich membrane Di-4-ANEPPDHQ |
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