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Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats |
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| Authors: | Yan-Fei Mao Xing-Feng Zheng Jian-Mei Cai Xiao-Ming Deng Lai Jiang Xue-Jun Sun |
| Affiliation: | a Department of Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, PR China b Chinese PLA Institute of Burn Surgery & Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, PR China c Department of Diving Medicine, The Second Military Medical University, Shanghai 200433, PR China d Department of Anesthesiology, Changhai Hospital, Shanghai 200433, PR China e Department of Neurosurgery, Loma Linda University, Loma Linda, CA 92350, USA |
| Abstract: | Objective. Hydrogen has been reported to selectively reduce the hydroxyl radical, the most cytotoxic of reactive oxygen species. In this study we investigated the effects of hydrogen-rich saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats. Methods. Male Sprague-Dawley rats (n = 30, 200-220 g) were divided randomly into three experimental groups: sham operated, intestinal I/R plus saline treatment (5 ml/kg, i.v.), and intestinal I/R plus hydrogen-rich saline treatment (5 ml/kg, i.v.) groups. Intestinal I/R was produced by 90 min of intestinal ischemia followed by a 4 h of reperfusion. Results. Hydrogen-rich saline treatment decreased the neutrophil infiltration, the lipid membrane peroxidation, NF-κB activation and the pro-inflammatory cytokine interleukin IL-1β and TNF-α in the lung tissues compared with those in saline-treated rat. Conclusion. Hydrogen-rich saline attenuates lung injury induced by intestinal I/R. |
| Keywords: | Intestinal ischemia/reperfusion Oxidative stress Lung injury Antioxidant Hydrogen-rich saline |
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