| 糖尿病大鼠心房肌细胞心房特殊颗粒和心房肽免疫反应强度的观察 |
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| 引用本文： | 庾照学,曾庆云,丁成萦,杨家齐.糖尿病大鼠心房肌细胞心房特殊颗粒和心房肽免疫反应强度的观察[J].中国组织化学与细胞化学杂志,1996(2). |
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| 作者姓名： | 庾照学 曾庆云 丁成萦 杨家齐 |
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| 作者单位： | 武汉冶金医专解剖学教研室 武汉430080(庾照学)，湖北医科大学解剖学教研室 武汉430077(曾庆云，丁成萦，杨家齐) |
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| 摘 要： | 本研究运用透射电镜及立体计量学方法结合免疫组化技术对糖尿病大鼠右心耳肌细胞心房特殊颗粒(ASG)和心房肽(ANP)免疫反应强度进行了观察和定量研究.实验动物为体重150～250克之间的SD大鼠,糖尿病的诱导采用四氧嘧啶(150mg/kg)右腹股沟区皮下注射.电镜超微结构发现糖尿病未治疗组均出现线粒体肿胀、肌原纤维缩短等病理性改变.ASG膜溶解、排空等现象多见,ASG体密度明显减少.免疫组化分析表明糖尿病未治疗组心肌细胞ANP免疫反应强度减弱.胰岛素治疗组各指标与对照组相比均无显著差别.
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| 关 键 词： | 心房肽(ANP) 糖尿病 立体计量 免疫组化 超微结构 大白鼠 |
OBSERVATION OF ATRIAL SPECIFIC GRANULES AND IMMUNOREACTIVE INTENSITY OF ANP IN THE ATRIAL CARDIOCYTICS OF DIABETIC RATS |
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| Yu Zhaoxue Zhen Qinyun Din Chengyin Yang Jiaqi.OBSERVATION OF ATRIAL SPECIFIC GRANULES AND IMMUNOREACTIVE INTENSITY OF ANP IN THE ATRIAL CARDIOCYTICS OF DIABETIC RATS[J].Chinese Journal of Histochemistry and Cytochemistry,1996(2). |
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| Authors: | Yu Zhaoxue Zhen Qinyun Din Chengyin Yang Jiaqi |
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| Abstract: | Atrial specia granules (ASG) and immunoreactive intensity of atrial natriuretic peptide (ANP) in right atrial auricle of rats with diabetes Mellitus were quantitatively studied. The results showed that the ultrastructure of ASG was changed. ANP reactive intensity and ASG density were significantly decreased in all groups with diabetes mellitus. |
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| Keywords: | Atrial natriuretic peptide (ANP) Quantitative stereological method Immunohistochemistry Diabetes meliitus Rats |
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