Anion permeation limits the uncoupling activity of fatty acids in mitochondria. |
| |
| Authors: | P Sch?nfeld |
| |
| Affiliation: | Institut für Biochemie, Medizinischen Akademie Magdeburg, Germany. |
| |
| Abstract: | The action of such membrane-permeant cations as tetraphenyl phosphonium and dibenzyldimethyl ammonium upon fatty acid-uncoupled respiration has been studied with oligomycin-inhibited rat liver mitochondria. Both cations enhance fatty acid-stimulated respiration. This synergistic effect is explained by a facilitated permeation of the fatty acid anion across the inner membrane due to an ion-pair complex. It is concluded that fatty acid uncoupling in rat liver mitochondria is limited by fatty acid anion permeation. |
| |
| Keywords: | |
|
|
