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Lack of B-cell participation in acute lymphocyte choriomeningitis disease of the central nervous system. |
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| Authors: | E D Johnson A A Monjan H C Morse |
| Institution: | 1. Neuroimmunology Branch, National Institute of Neurological and Communicative Disorders and Stroke, and the Laboratory of Microbial Immunity, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 USA;2. Division of Infectious Diseases, Department of Epidemiology, School of Hygiene and Public Health, Johns Hopkins University, Baltimore, Maryland 21218 USA |
| Abstract: | The pattern of acute lymphocytic choriomeningitis (LCM) virus-induced central nervous system (CNS) disease was studied in BALB/c mice rendered deficient in B cells and incapable of producing a humoral immune response. The CNS disease in mice treated from birth with goat anti-mouse μ-chain globulin (μ-suppressed mice) was clinically and histopathologically indistinguishable from that of controls. This result demonstrates that neither B cells nor antibody participate in the pathogenesis of acute LCM of the CNS. These observations support the view that the host cell-mediated response to viral antigens is solely responsible for acute CNS disease induced by the intracerebral inoculation of LCM virus. |
| Keywords: | Reprints can be obtained from Dr Eugene D Johnson Neuroimmunology Branch NINCDS Building 36 Room 5D-12 National Institutes of Health Bethesda Maryland 20014 |
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