|
|||||
|
|
Transition state isosteres of the gamma-glutamyl peptide bond hydrolysis: synthesis and characterization of the psi (CH2NH) pseudopeptide analogue of glutathione. |
|
| Authors: | Ivana Cacciatore Antonio Di Stefano Grazia Luisi Francesco Pinnen Piera Sozio |
| Institution: | Dipartimento di Scienze del Farmaco, Università degli Studi G. D'Annunzio, 66013 Chieti, Italy. |
| Abstract: | The fully deprotected glutathione analogue containing the aminomethylene unit as transition state isostere of the gamma-Glu-Cys peptide bond was synthesized for the first time and characterized in both the reduced and oxidized forms. |
| Keywords: | γ‐glutamyl peptide bond glutathione reduced peptides transition state analogue |