Grazing incidence X-ray diffraction of highly aligned phospholipid membranes containing the antimicrobial peptide magainin 2 |
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| Authors: | C. Münster J. Lu B. Bechinger T. Salditt |
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| Affiliation: | Center for NanoScience and Sektion Physik der Ludwig-Maximilians-Universit?t München, Geschwister-Scholl-Platz 1, D-80539 München, Germany, DE
Max-Planck Institut für Biochemie, Am Klopferspitz 18a, D-82152 Martinsried, Germany, DE
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| Abstract: | We present the first study of grazing incidence X-ray diffraction on a model system of phospholipid membranes and antimicrobial peptides. For this purpose, highly oriented multilamellar samples have been prepared on solid substrates. By this technique, the short-range order of the lipid chains in the fluid Lα phase can be investigated quantitatively, including not only the mean distance between acyl chains, but also the associated correlation length. The short-range order in lecithin is found to be severely affected by the amphiphilic peptide magainin 2. Received: 7 June 1999 / Revised version: 6 September 1999 / Accepted: 17 September 1999 |
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| Keywords: | Membrane structure X-ray diffraction Antibiotic peptides Lipid-peptide interaction |
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