Effect of dopamine agonists and antagonists on DOPA formation in the substantia nigra |
| |
Authors: | A Argiolas M R Melis F Fadda G Serra G L Gessa |
| |
Affiliation: | Institute of Pharmacology, University of Cagliari, Cagliari, Italy;Institute of Physiology, University of Cagliari, Cagliari, Italy |
| |
Abstract: | Abstract: The effect of different psychotropic drugs on the rate of DOPA accumulation after administration of a decarboxylase inhibitor (NSD 1015) was compared in the substantia nigra (SN) and caudate nucleus (CN) by a new radioenzymatic method. Inhibition of monoamine oxidase with pargyline or stimulation of dopamine (DA) receptors with apomorphine, N -n-propyl-norapomorphine or d -amphetamine reduced DOPA formation in the CN and SN to the same extent. Vice versa, both inhibition of DA receptors with haloperidol or (-)sulpiride and depletion of DA concentration with reserpine enhanced DOPA formation to a greater extent in the CN than in the SN. Apomorphine antagonized not only the effect of haloperidol and (-)sulpiride, but also, and even more effectively, that of reserpine. The results indicate that DA synthesis in the SN is controlled by both end-product inhibition and DA receptor-mediated mechanisms. |
| |
Keywords: | Dopamine DOPA Substantia nigra DA agonists DA antagonists |
本文献已被 PubMed 等数据库收录! |
|