|
|||||
|
|
Structural requirement of tunicamycin V for MraY inhibition |
|
| Authors: | Kazuki Yamamoto Akira Katsuyama Satoshi Ichikawa |
| Institution: | 1. Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan;2. Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan |
| Abstract: | Elucidating a structure-activity relationship study by evaluating a series of truncated analogues is a simple but important and effective tactic in medicinal chemistry based on natural products with a large and complex chemical structure. In this study, a series of truncated analogues of tunicamycin V were designed and synthesized and their MraY inhibitory activity was investigated in order to gain insight into the effect of these moieties on MraY inhibition. |
| Keywords: | Nucleoside Natural products Antibacterial Structure-activity relationship Enzyme inhibitor |
| 本文献已被 ScienceDirect 等数据库收录！ | |