Enhanced cytotoxicity of gold porphyrin complexes after inclusion in cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles |
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Authors: | Robert Granet René Faure Gautier Mark-Arthur Ndong Ntoutoume Jean Pierre Mbakidi David Yann Leger Bertrand Liagre Vincent Sol |
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Institution: | Université de Limoges, Laboratoire PEIRENE, EA 7500, F-87000 Limoges, France |
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Abstract: | A new gold nanoparticle-based construct has been designed to hydrophobic drugs delivery into cancer cells. Cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles (AuNP@PEI@CD) have been used to encapsulate hydrophobic tetrapyrrolic compounds consisting of gold complexes of 5,10,15,20-tetraphenyl porphyrin (AuTPPCl) and 5-(4-acetoxyphenyl)-10,15,20-triphenyl porphyrin (AuTPPOAcCl). These two nanoparticles have been tested for their cytotoxic activities against the two colorectal cancer cell lines HT-29 and HCT-116 and have shown significant increases in toxicity when compared to the corresponding non-vectorized tetrapyrrolic macrocycles. |
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Keywords: | Gold nanoparticles PEI Gold porphyrins Colorectal cancer Microwave |
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