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Endogenous glucocorticoids decrease skeletal angiogenesis,vascularity, hydration,and strength in aged mice
Authors:Robert S Weinstein  Chao Wan  Qinglan Liu  Ying Wang  Maria Almeida  Charles A O’Brien  Jeff Thostenson  Paula K Roberson  Adele L Boskey  Thomas L Clemens  Stavros C Manolagas
Institution:1. Division of Endocrinology and Metabolism, Center for Osteoporosis and Metabolic Bone Diseases, Department of Internal Medicine, Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, AR, USA;2. Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA;3. Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA;4. Hospital for Special Surgery, New York, NY, USA
Abstract:
Keywords:11β  ‐hydroxysteroid dehydrogenase  aging  angiogenesis  apoptosis  bone histomorphometry  glucocorticoids  hydraulic support  osteoporosis
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