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Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists
Authors:Anna-Katharina Apel  Robert KY Cheng  Christofer S Tautermann  Michael Brauchle  Chia-Ying Huang  Alexander Pautsch  Michael Hennig  Herbert Nar  Gisela Schnapp
Institution:1. Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorferstrasse 65, 88397 Biberach, Germany;2. LeadXpro AG, PARK InnovAARE, 5234 Villigen, Switzerland;3. Swiss Light Source, Paul Scherrer Institute, 5232 Villigen, Switzerland
Abstract:
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  • Keywords:chemokine receptor  CCR2  GPCR  protein engineering  serial crystallography  MK-0812
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